Synthesis, Characterization And Computational Study Of Cobalt(Ii), Copper(Ii), Nickel(Ii), Vanadium(Iv) And Zinc(Ii) Complexes Of Quinoline Derivative Ligands For Biological Applications

Abstract

The Application Of Transition Metal Complexes As Biochemical, Medicinal, Analytical, Pharmaceutical, Agricultural And Antimicrobial Agents Has Recently Become Center Of Interest For Researchers And Innovators. In This Aspect, Quinoline Ligands Containing Imine Are Important Classes Of Biologically Active Molecules That Have Attracted Attention Of Bioinorganic, Pharmaceutical And Medicinal Chemists Due To Their Familiar Coordination Behavior And Wide Range Of Pharmacological Properties. In This Phd Dissertation Work, Ten(10) Series Of Novel Transition Metal Complexes Of Zn(Ii), Cu(Ii), Co(Ii), Ni(Ii), And V(Iv) Were Prepared From Quinoline Derivative Ligands [(E)-2-(((2-((2-Hydroxyethyl)Amino)Quinolin-3-Yl)Methylene)Amino)Ethan-1-Ol, (H3l) (L1) And 2-((2-Hydroxyethyl)Amino)Quinoline-3-Carbaldehyde (H2l) (L2)] In 1:1 And 1:2 Metal?�?To-Ligand Ratio In Methanol Respectively And Characterized With Uv-Visible Spectroscopy, Fluorescence Spectroscopy, 1hnmr Spectroscopy, 13cnmr Spectroscopy, Ftir Spectroscopy, Powder X Ray Diffraction (Pxrd), Scanning Electron Microscopy-Energy Dispersive X-Ray Spectroscopy (Sem-Edx), Mass Spectroscopy (Ms), Thermal Analyzers, Molar Conductance And Melting Point. In Addition, Computational (Drug Likeness, Dft And Molecular Docking) Analysis Were Also Carried Out To Get Further Insights And To Support The Analyses Of The Results. The Structural Features, The Crystallite Size, And Elemental Composition Of The Metal Complexes Were Deduced From Molar Conductance, Ftir, Mass Spectroscopy, Powder Xrd, Thermal Analyzers And Edx Studies. Powder Xrd Results Indicate The Average Crystallite Sizes Of Complexes 1 ?�? 5, 7, 8 And 10 Are 28, 34, 22, 37, 8, 23, 9 And, 23 Nm, Respectively. The Spectral Data Revealed That The Ligands Adopted A Tridentate (L1) And Bidentate (L2) Fashion When Binding To Metal Ions Via The Nitrogen Atom And The Oxygen Atom Of Deprotonated Hydroxyl Group (O-H). In Vitro Antibacterial Activity Analysis Of Both The Ligands And Their Synthesized Complexes Were Studied By Employing The Disc Diffusion And Agar Dilution Methods, In Which The Complexes Exhibited Better Activity Than The Precursor Ligands, That All The First Five (Zn(Ii), Cu(Ii), Co(Ii), Ni(Ii) And V(Iv)) Of L1 Complexes Exhibited Activity Ranging From Low To High Mean Inhibition Zones, With 7.32 ?? 0.90 Mm At 150 ??G/Ml And 20.65 ?? 0.18 Mm At 300 ??G/Ml. All The Zn(Ii), Cu(Ii), Co(Ii), Ni(Ii) Complexes Exhibited Very Good Activities With Pseudomonas Aeruginosa (18.85 ?? 0.34, 20.65 ?? 0.18, 18.62 ?? 0.19 And 15.64 ?? 0.22 Mm Diameter At Concentration Of 300 ??G/Ml, Respectively) Compared To Free Ligand With Mean Inhibition Zone Of 6.24 ?? 0.39mm Diameter. Similarly, The Complexeszn(Ii), Cu(Ii), Co(Ii), Ni(Ii) Of Ligand (L2) Exhibited Activities Ranging From Medium To Xviihigh Mean Inhibition Zones, With 11.79 ?? 1.07 Mm At 100 ??G/Ml And 20.90 ?? 2.00 Mm At 200 ??G/Ml. All The Complexes Exhibited Good Activities With Pseudomonas Aeruginosa (20.75 ?? 2.05, 20.90 ?? 2.00, 20.75 ?? 2.07 And 18.90 ?? 2.06 Mm Diameter At Concentration Of 200 ??G/Ml, Respectively) Compared To Free Ligand With Mean Inhibition Zone Of 9.60 ?? 2.00mm Diameter, But Among These Cu(Ii) Complex Showed Higher Percent Activity Index (Ai = 62, 90%), Than All Zn(Ii) (Ai = 54, 82%), Co(Ai = 54, 81%) And Ni(Ii) (Ai = 41, 68%) With Both Escherichia Coli, And Pseudomonas Aeruginosa, Respectively. Furthermore, All The Complexes (1 ?��? 10) Were Also Evaluated For Their Antioxidant Properties Using Dpph Assay In Which All Metal Complexes Showed Higher Antioxidant Activities Than The Free Ligands. Among These: Zn(Ii