Chemical Investigation Of The Essential Oil And Solvent Extracts From The Whole Aerial Part Of Chenopodium Ambrosioides

Abstract

In This Study, The Whole Aerial Part Of A Medicinal Plant Known As Chenopodium Ambrosioides, Which Grows In The Wild And Collected From Around Gedo Town In The West-Shoa Zone, Oromia Region Was Investigated. C. Ambrosioides Is An Herbaceous Shrub That Belongs To Plants Of The Family Chenopodiaceae, Grows Wild In Central And South America. It Has Been Used For Centuries By Native People As Dietary Condiments And As Traditional Medicine. The Plant Has Been Used As Antihelmintics, As Anti-Inflammatory, As Anti-Tumoral, As Healer And As Anti Leishmanial Which Is Due To The Presence Of A Compound Known As Ascaridole. Previous Studies Conducted On The Essential Oil Of The Seeds Of The Plant Revealed Presence Of A Number Of Low Molecular Weight Terpenes. Since No Study Has Hitherto Been Conducted On This Medicinal Plant In Ethiopia, The Whole Aerial Part Of The Plant Was Subjected To Hydrodistillation And Solvent Extraction Followed By Gc-Ms Analysis, Tlc Analysis, Chromatographic Separations On Silica Gel Columns Eluted By Organic Solvents And Preparative Tlc Separations. Thus, Three Compounds Could Be Identified From The Essential Oil By Gc-Ms Analysis. These Were 1-Methyl-4(1-Methyledene)-Cyclohexane, 1-Methyl-2(1-Methylethyl)-Benzene And 6-Isopropylidene-1-Methyl-Bicyclo[3,1,0]Hexane.In Addition, A New Compound, Cac-1, Was Isolated From The Chloroform Extract Of The Aerial Parts Of The Plant By Repeated Chromatography. The Structure Of Cac-1 Has Been Elucidated By Extensive Analysis Of The Data From Its 1h-Nmr, 13c-Nmr, Dept Experiments. In Addition Structural Information About The Compound Has Been Obtained From Its Infrared Spectrum. By Interpreting The Spectroscopic Data Cac-1 Has Been Identified As 1-(4-Ethoxymethyl-Phenyl)-2(4-Methyl-Bicyclo [1,1,1]Pent-2-Yl)-Ethanone.