Synthesis of Phenylhydrazone Schiff Base Derivative, their Copper(II) Complexes and Antibacterial Activity Investigation

Abstract

In present study hydrazone of phenylhydrazine, 4-methoxybenzaldehyde, 4-nitrobenzaldehyde and their respective benzenesulfanohydrazones and Cu(II) complexes were synthesized. All the ligands were characterized by IR, 1H NMR, and 13C NMR. The Cu(II) complexes were also characterized by elemental analysis and IR. The IR spectra of ligand and its metal complexes imply that the Schiff base ligand behaves as basic bidentate ligand coordination through the azomethine nitrogen atom and nitrogen atom. In-vitro antibacterial activity was carried out for all the synthesized compounds by using disc diffusion method against K.pneumoniae, E.coli, P.aeruginosa, and S. aureus. Cu(II) complexes of compound 34 showed better activity (15mm zone of inhibition) against K.pneumoniae compared to the standard ceftriaxone (11 mm zone of inhibition) whereas the remaining compounds showed less activity compared to the standard. The Cu(II) complexes exerted excellent antibacterial activities than the ligands which might be due to increase in lipophilicity of the compound.